糖敏方治疗气阴两虚证2型糖尿病临床观察

Clinical Observation of Tangmin Prescription for Type 2 Diabetes Mellitus with Dual Deficiency of Qi and Yin Syndrome

目的:观察气阴两虚证2型糖尿病患者在辨证施治的基础上选用糖敏方治疗的临床疗效及其对胰岛素敏感性的影响。方法:采用随机对照试验方法,将纳入观察的61例气阴两虚证2型糖尿病患者分为2组。2组均予饮食及运动控制,对照组30例给予二甲双胍片治疗,治疗组31例给予糖敏方联合二甲双胍片治疗。2组均治疗8周后比较空腹血糖(FBG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、胰岛素敏感指数(ISI)、稳态模型胰岛素抵抗(HOMA-IR)指数、中医证候疗效的变化。结果:治疗组中医证候疗效总有效率87.10%,优于对照组50.00%(P<0.05);2组治疗后FBG、P2hBG、HbA1c、FINS、ISI、HOMA-IR指标均较治疗前改善(P<0.05),其中P2hBG、FINS、ISI、HOMA-IR指标及中医症状疗效积分提示治疗组改善更为显著(P<0.05)。结论:糖敏方联合二甲双胍片治疗气阴两虚证2型糖尿病疗效优于单用二甲双胍片治疗,能有效降低气阴两虚证2型糖尿病患者P2hBG、改善胰岛素抵抗,提高胰岛素敏感性,在改善中医症状方面具有显著疗效。

Objective:To observe the clinical effect of Tangmin prescription based on syndrome differentiation for patients with type 2 diabetes mellitus with dual deficiency of qi and yin syndrome and its effect on insulin sensitivity. Methods:A total of 61 cases of patients with type 2 diabetes mellitus with dual deficiency of qi and yin syndrome were divided into the control group and the treatment group according to randomized controlled trials,30 and 31 cases in each group respectively. Both groups were given diet and exercise control;the control group was treated with metformin tablets,and the treatment group was treated with Tangmin prescription combined with metformin tablets. After eight-week treatment,the changes in fasting blood glucose(FBG), postprandial 2-hour blood glucose(P2 hBG), hemoglobin A1 c(HbA1 c), fasting insulin(FINS), insulin sensitivity index(ISI), Homeostasis model assessment of insulin resistance(HOMA-IR) and curative effect of Chinese medicine syndromes in the two groups were compared. Results:The total effective rate of Chinese medicine syndromes was87.10% in the treatment group,better than that of 50.00% in the control group(P<0.05). After treatment,the indexes of FBG, P2 hBG, HbA1 c, FINS, ISI and HOMA-IR in the two groups were improved when compared with those before treatment(P < 0.05), and the improvement of P2 hBG,FINS,ISI,HOMA-IR and Chinese medicine syndrome scores in the treatment group was more significant(P<0.05). Conclusion:For patients with type 2 diabetes mellitus with dual deficiency of qi and yin syndrome,the therapy of Tangmin prescription combined with metformin tablets has better curative effect than that of simple metformin tablets. It can effectively reduce their P2 hBG, improve insulin resistance and insulin sensitivity,which has significant curative effect in improving Chinese medicine symptoms.