骨髓与脂肪间充质干细胞治疗眼病的研究进展

Research advancement of bone marrow and adipose-derived mesenchymal stem cells in the treatment of eye diseases

间充质干细胞(MSCs)具有很强的增殖能力,并且可以分化成不同类型的细胞,为动物个体发育中体细胞的更新提供了极大的可塑性。基于其独特的生物学特性,现在被用于治疗各种创伤性和退行性疾病,其临床应用潜能几乎是无限的。本文就骨髓和脂肪组织来源的两种间充质干细胞(BMSCs和ADSCs),讨论了其应用于眼科各种疾病的临床治疗、给药方法及其获得途径和安全性的相关研究。

Mesenchymal stem cells(MSCs)are multipotent cells with high proliferation ability that can differentiate into a variety of cell types.Thus great plasticity was provided for the regeneration of somatic cells in animal individual growth.Recently,MSCs have been applied to the treatment of traumatic and degenerative diseases on account of its distinct biologic peculiarity.The cells have tremendous potential in the clinical application.This article reviewed clinical treatment of ophthalmic diseases,administration route,methods of acquiring and security about two of MSCs derived from bone marrow and adipose tissue(BMSCs and ADSCs).