阿奇霉素雾化熏蒸对睑板腺功能障碍的疗效评价

Evaluation of the efficacy of azithromycin aerosol fumigation on meibomian gland dysfunction

目的:评价阿奇霉素雾化熏蒸联合睑板腺按摩治疗睑板腺功能障碍(MGD)的有效性及安全性。方法:前瞻性研究。选择2019-01/06在本院的47例中、重度MGD患者进行阿奇霉素雾化熏蒸联合睑板腺按摩治疗。在基线、治疗1、3mo时分别记录患者眼表疾病指数问卷(OSDI)、非侵入式泪膜破裂时间(NI-BUT)、泪河高度以及睑板腺萎缩率。结果:治疗1mo的OSDI为21.43±13.14分、首次NI-BUT为9.03±6.09s、平均NI-BUT为9.72±4.05s、泪河高度为0.24±0.09mm,与基线相比有差异(均P<0.05);治疗3mo的OSDI为23.02±11.41分、首次NI-BUT为7.80±4.82s、平均NI-BUT为10.25±4.78s、泪河高度为0.24±0.09mm,与基线相比有差异(均P<0.05);治疗1mo与3mo OSDI、首次NI-BUT、平均NI-BUT和泪河高度均无差异(均P>0.05)。治疗前后的睑板腺萎缩率无差异(均P>0.05)。结论:阿奇霉素雾化熏蒸联合睑板腺按摩可有效改善中、重度MGD患者的临床症状,并且增加首次NI-BUT、平均NI-BUT和泪河高度。

AIM:To evaluate the efficacy and safety of azithromycin aerosol fumigation combined with meibomian gland massage in the treatment of meibomian gland dysfunction(MGD).METHODS:In this prospective study,47 patients with moderate to severe MGD were treated with azithromycin aerosol fumigation combined with meibomian gland massage.The ocular surface disease index(OSDI)questionnaire,noninvasive tear breakup time(NI-BUT),tear meniscus height and atrophic rate of meibomian glands were recorded at baseline,at 1mo after treatment,and at 3mo after treatment.RESULTS:The OSDI was 21.43±13.14,the first NI-BUT was 9.03±6.09s,the average NI-BUT was 9.72±4.05s,and the tear meniscus height was 0.24±0.09mm after 1mo of treatment.The OSDI was 23.02±11.41,the first NI-BUT was 7.80±4.82s,the average NI-BUT was 10.25±4.78s,and the tear meniscus height was 0.24±0.09mm after 3mo of treatment.Compared with the baseline,the difference was statistically significant(all P<0.05);There was no significant difference in OSDI,first NI-BUT,average NI-BUT and tear meniscus height between 1mo after treatment and 3mo after treatment(all P>0.05).Compared with baseline,there was no significant improvement in atrophic rate of meibomian glands after 1mo of treatment and 3mo after treatment(all P>0.05).In addition,azithromycin aerosol fumigation administration was well tolerated and no adverse reactions were observed during follow-up(all P>0.05).CONCLUSION:Azithromycin aerosol fumigation combined with meibomian gland massage can effectively improve the clinical symptoms and increase first NI-BUT,average NI-BUT,tear meniscus height of patients with moderate to severe MGD.