血液Aβ、tau在AD诊断中的价值

The value of plasma Aβand tau in the diagnosis of Alzheimer’s disease

阿尔茨海默病是一种严重危及老年健康的神经变性疾病,是老年痴呆中最常见的类型。AD的发病率随年龄的增加而增长,由于其发病率随社会老龄化而逐步上升,目前已经成为重要的社会公共卫生问题。虽然目前已有多种药物治疗能够减轻AD症状,但无一能够改变疾病进程。因此,早期发现、早期诊断、早期治疗就显得尤为重要。目前通过检测血液中的相关病理性蛋白来诊断AD已经成为国际研究的热点,本文将对近年来关于AD血液标志物Aβ、Tau蛋白的相关研究作一简要综述,并探讨未来可能的研究方向。

Alzheimer's disease is a kind of neurodegenerative disease which seriously endangers the health of the elderly.It is the most common type of Alzheimer's disease.The incidence rate of AD increases with age.AD has become an important social public health problem as the incidence rate increases with the aging of society.Although there are many kinds of drugs to alleviate the symptoms of AD,none of them can modify the course of the disease.Therefore,early detection,early diagnosis and early treatment are particularly important.At present,the diagnosis of AD by detecting the related pathological proteins in blood has become a hot spot in international research.This article will briefly review the recent studies on the blood markers(Aβand tau protein)of AD,and discuss the possible research directions in the future.