红霉素与阿奇霉素治疗肺炎支原体肺炎的效果

Efficacy of Erythromycin and Azithromycin in theTreatment of Mycoplasma Pneumoniae Pneumonia

目的研究采用红霉素与阿奇霉素治疗小儿肺炎支原体肺炎的效果。方法研究时段是2016年10月—2019年10月,研究对象是本院接收的100例小儿肺炎支原体肺炎患儿,按照"就诊先后顺序"随机分观察组(阿奇霉素序贯疗法)与对照组(红霉素序贯疗法)各50例,两组治疗效果比较。结果治疗前比较两组炎性因子、免疫球蛋白水平差异无统计学意义(P> 0.05);治疗后与对照组比较,观察组IL-6、CRP、TNF-α及IFN-γ指标较低;Ig A、Ig G及Ig M指标较高,总有效率较高,P <0.05。观察组不良反应发生率较对照组低,且差异具有统计学意义(P <0.05)。结论与红霉素序贯疗法比较,采用阿奇霉素序贯疗法治疗小儿肺炎支原体肺炎能提高疗效、稳定病情,降低炎性因子水平,具有较高的临床价值。

Objective To study the effect of erythromycin and azithromycin in children with mycoplasma pneumoniae pneumonia in children.Methods The study period was from October 2016 to October 2019.The study object was 100 children with mycoplasma pneumoniae pneumonia received by our hospital.The observation group(azithromycin sequential therapy)and the control group(erythromycin sequential Therapy)was performed in 50 patients each,and the treatment effects of the two groups were compared.Results There were no differences in inflammatory factors and immunoglobulin levels between the two groups before treatment,P>0.05;compared with the control group after treatment,the indicators of IL-6,CRP,TNF-αand IFN-γwere lower in the observation group;IgA,IgG and IgM indicators were higher,and the total effective rate was higher,P<0.05.The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with erythromycin sequential therapy,azithromycin sequential therapy in children with mycoplasma pneumoniae pneumonia can improve the efficacy,stabilize the condition,and reduce the level of inflammatory factors,which has higher clinical value.