女性非小细胞肺癌与雌激素的相关性

Correlation of Estrogen and Female Non-small Cell Lung Cancer

研究发现雌激素及雌激素受体在非小细胞肺癌(NSCLC)有表达,并与其发生发展及预后相关。一些基础及临床研究已证实,在NSCLC中雌激素受体通路与表皮生长因子受体信号通路存在关联。NSCLC患者接受化疗、表皮生长因子受体酪氨酸激酶抑制剂治疗的同时联合拮抗雌激素治疗能够逆转耐药,提高疗效并改善预后。全文就雌激素及雌激素受体与NSCLC发生发展及预后的关系,以及拮抗雌激素治疗在NSCLC中的应用进行综述。

Studies have found that estrogen and estrogen receptor expressed in non-small cell lung cancer and associated with the development and prognosis of the cancer. Some basic and clinical studies have confirmed the association between estrogen receptor pathway and epidermal growth factor receptor pathway in non-small cell lung cancer. It has been observed that concurrent antagonistic estrogen therapy may reverse drug resistance and improve clinical efficacy and prognosis in breast cancer patients receiving chemotherapy or EGFR-TK inhibitors.This article reviews the relationship of estrogen and estrogen receptor expression with the tumor development and prognosis and the application of antagonistic estrogen therapy in female nonsmall cell lung cancer.