摘要
Lobane-type diterpenoids are not frequently discovered from marine soft corals. In this paper, three new lobane type diterpenes, 13-methoxyloba-8,10,15(16),17(18)-tetraene(1), 8,10,13(15)Z,16 E-lobatetraene(2) and 19-hydroxy-lobatetraene(3), and a new natural compound, 17,18-epoxyloba-16-acetoxy-8,10,13(15)-trien(4), co-occurring with a known related diterpenoid, 18-methoxyloba-8,10,13(15),16(17)-tetraene(5), were isolated from the South China Sea soft coral Sinularia polydactyla. The structures of new compounds were determined by extensive spectroscopic analysis and by comparison with those reported in the literature. In bioassay, all the isolates were inactive on antibacterial, PTP1 B inhibitory, and immunological activities. This study increased the chemical diversity of marine diterpenoids.
基金
supported by the National Key Research and Development Program of China (No. 2018YFC-0310903)
the Natural Science Foundation of China (Nos. 81991521
21672230
and 81520108028)
the NSFC/CNRS Joint Project (No.81811530284)
the SKLDR/SIMM Project (No. SIMM1903ZZ-04)
Shanghai Rising-Star Program (No. 20QA1411100)
SA-SIBS Scholarship Program
Syngenta-SIMM-Ph D Studentship Project。