细胞系与婴幼儿血管瘤动物模型研究进展

Progress in animal models of cell lines and infantile hemangioma

婴幼儿血管瘤是婴幼儿最常见的先天性良性肿瘤,具有可预测的疾病演变和持续时间。目前对于婴幼儿血管瘤发展、增殖和消退的基本认识尚不充分,迫切需要一种理想的活体婴幼儿血管瘤模型,为观察其细胞、分子基础和药物机制研究提供一个标准平台。截至目前,一个完全模拟婴幼儿血管瘤生物学行为的模型尚未建立成功,但已有研究为婴幼儿血管瘤的发病机制和临床治疗奠定了坚实基础。该文总结了近年来相关细胞系与婴幼儿血管瘤动物模型的研究进展及其临床价值,以及可能在未来用于婴幼儿血管瘤模型构建的有利因素,为后续研究婴幼儿血管瘤在动物模型的选择上提供最新参考。

Infantile hemangioma is the most common benign tumors in infancy with predictable disease evolution and duration.At present,the basic understanding of the development,proliferation and regression of infantile hemangioma is not sufficient,an ideal lively human infantile hemangioma model which could provide a standard platform for observation of cellular,molecular basis of infantile hemangioma development and drug mechanism is urgently needed.Up to now,a model that completely mimics the biological behavior of infantile hemangiomas has not been successfully established,but the existing research progress has laid a solid foundation for the pathogenesis of hemangioma and clinical targeted therapy.In this paper,the research progress of cell line and animal model of infantile hemangioma and its clinical value in recent years were summarized,as well as the favorable factors that may be used in the construction of infant hemangioma model in the future,providing the latest reference for the selection of animal model of infantile hemangioma.