NF-κB介导的炎症反应与颅内动脉瘤

NF-κB Mediated Inflammatory Response and Intracranial Aneurysms

核因子κB(NF-κB)几乎存在于所有的动物细胞内,参与细胞对外界刺激的响应,在细胞的炎症反应和免疫应答中均发挥关键作用。颅内动脉瘤的发生、发展受多种因素的影响,其中炎症反应对动脉壁的浸润发挥了重要作用,而NF-κB基因启动子表观水平的改变是调节动脉瘤壁炎症反应的遗传学因素之一。NF-κB可能通过对炎症细胞和炎症因子的调控对颅内动脉瘤的发生、发展甚至破裂产生影响。关于颅内动脉瘤的发病机制目前尚未完全阐明,很大程度上限制了颅内动脉瘤治疗途径及治疗方式等的发展。

Nuclear factor-κB(NF-κB)is found in almost all animal cells and participates in the cellular response to external stimuli,playing a key role in the cellular inflammation and immune responses.During the development of intracranial aneurysm,it is affected by many factors,among which the inflammatory response plays an important role in the infiltration of the arterial wall,and the change in the epigenetic level of the NF-κB gene promoter is one of the genetic factors to regulate the inflammatory response of the aneurysm wall.NF-κB may affect the occurrence,development and even rupture of intracranial aneurysms by regulating some inflammatory cells and inflammatory factors.At present,the pathogenesis of intracranial aneurysms has not been fully elucidated,which has greatly limited the development of treatment approaches and methods for intracranial aneurysms.