炎性肠病肝胆系统并发症相关机制的研究进展

Research Advances in Mechanism of Hepatobiliary Complications of Inflammatory Bowel Disease

炎性肠病(IBD)是一种主要累及直肠、结肠和回肠等的慢性炎症性疾病,最常见的IBD主要包括克罗恩病和溃疡性结肠炎,其发病的病理生理机制目前尚未明确。除肠道病变外,IBD还可能产生肠外多系统并发症,而肝胆系统并发症是IBD最常见的肠外表现。近年来,IBD与肝胆系统并发症的相关性及发病机制的研究日趋增多,通过遗传、免疫及环境因素等多方面的综合深入研究,拓展了人们对IBD和肝胆疾病并发症的认识,在IBD的临床治疗方面发挥了关键性的作用,但仍缺乏系统、全面的总结。

Inflammatory bowel disease(IBD)is a chronic inflammatory disease that mainly involves the rectum,colon and ileum.The most common types include Crohn′s disease and ulcerative colitis,the pathophysiological mechanism of which has not been clarified.In addition to intestinal lesions,IBD may also have multiple extraintestinal complications,and hepatobiliary complications are the most commonly seen.In recent years,the studies of the correlation between IBD and complications of hepatobiliary system and the pathogenesis have been increasing,such as the comprehensive research from genetic,immune,and environment factors,expanding knowledge of IBD and hepatobiliary complications,and playing a key role in the clinical treatment of IBD,although a systematic comprehensive summary is still in lack.