转录因子FoxO1在糖脂代谢及肥胖症中的研究进展

Research Progress of Transcription Factor FoxO1 in Glycolipid Metabolism and Obesity

叉头框转录因子O亚型1(FoxO1)作为人体重要的转录因子,参与细胞代谢、生长、分化、氧化应激、衰老、自噬等多种生理和病理过程,其转录活性受多个上游通路翻译后修饰和细胞核-质异位调节。FoxO1基因突变或蛋白异常表达在糖脂代谢及肥胖症等代谢性疾病的发生发展中起重要作用。目前代谢性疾病发病率高且控制欠佳,除饮食及运动外,无特效药。FoxO1在改善胰岛β细胞功能、改善胰岛素抵抗以及纠正脂代谢紊乱、干预肥胖症等方面发挥作用。因此,FoxO1可能为糖脂代谢及肥胖症的治疗提供新思路。

As an important transcription factor in human body,the forkhead box O1(FoxO1),is involved in a variety of physiological and pathological processes such as cell metabolism,growth,differentiation,oxidative stress,aging,autophagy,and so on.Its transcriptional activity is regulated by post-translational modification of multiple upstream pathways and nuclear-plasmid ectopia.FoxO1 gene mutation or abnormal protein expression plays an important role in the occurrence and development of metabolic diseases such as glucose and lipid metabolism and obesity.At present,the incidence of the metabolic diseases is high incidence and is poorly controlled.Except diet and exercise,there is no specific medicine.FoxO1 plays a role in improving the function of islet cells,improving insulin resistance,correcting the disorder of lipid metabolism,and intervening obesity.Therefore,FoxO1 may provide new ideas for the treatment of glucose and lipid metabolism and obesity.