摘要
Although mitochondria are known to play an important role in radiation-induced cellular damage[1,2],the mechanisms by which ionizing radiation modulates mitochondrial dynamics are largely unknown.In this study,human cervical carcinoma cell line HeLa was used to demonstrate the different modes of mitochondrial network in response to different quality radiations such as low linear energy transfer(LET)X-rays and high-LET carbon ions.Mitochondria fragmented into punctate and clustered ones upon carbon ion irradiation in a dose-and LET-dependent manner.In contrast,low-dose X-ray irradiation promoted mitochondrial fusion while mitochondrial fission was detected until the radiation dose was more than 1 Gy(Fig.1).
