摘要
Prostate cancer is the most commonly diagnosed cancer in worldwide men and radiation therapy is one of the most common definitive options for localized prostate cancer[1].MicroRNAs(miRNAs)are small non-coding RNAs that specifically regulate gene expression by directly cleaving the targeted mRNAs or inhibiting translation by interacting with the 3′untranslated regions(UTRs)of the mRNA targets to increase or inhibit their translation[2].Increasing evidence suggests that the expression levels of miRNAs significantly change when treated by X ray irradiation,which indicates that miRNAs may play a critical role in the DNA damage response in tumor radiation response[3].
基金
Key Program of National Natural Science Foundation of China(U1432248)
National Natural Science Foundation of China(11775280)
National Natural Science Foundation of China(11665003)。
