血炎性指标NLR、PLR及MHR与糖尿病性心肌病的相关性研究

Study on the correlation between blood inflammatory indexes NLR,PLR,MHR and diabetic cardiomyopathy

目的探究血炎性指标中性粒细胞计数与淋巴细胞计数比值(NLR)、血小板计数与淋巴细胞计数比值(PLR)及单核细胞计数与高密度脂蛋白-胆固醇比值(MHR)与糖尿病性心肌病(DCM)的相关性。方法选取2013年11月至2020年1月于广东医科大学附属医院就诊的DCM患者(DCM组)、2型糖尿病(T2DM)患者(T2DM组)及健康人群(健康组)各101例,对3组一般资料、NLR、PLR、MHR、血糖、血脂、血尿酸、胱抑素C和超声心动图(左室舒张功能及射血分数)、心电图(心律失常及ST-T改变)等指标进行分析。结果与健康组相比,DCM组NLR及MHR均显著升高(H=19.982、11.607,P均<0.05);与T2DM组相比,DCM组PLR较高(H=9.969,P<0.05)。Spearman等级相关分析表明,NLR与PLR呈正相关(r=0.644,P<0.001)。Logistic回归分析显示,舒张压、胱抑素C、NLR及左室舒张功能减退是DCM的危险因素(β=0.069、3.583、0.356、1.268,P均<0.01)。其中NLR每增加1个单位,糖尿病并发DCM的风险增加1.428倍。结论DCM患者NLR、PLR及MHR较高,NLR是DCM的独立危险因素。

Objective To explore the correlation of the blood inflammatory index neutrophil count and lymphocyte count ratio(NLR),platelet count and lymphocyte count ratio(PLR),monocyte count and high density lipoprotein-cholesterol ratio(MHR)and diabetic cardiomyopathy(DCM).Methods Patients with DCM(DCM group),patients with type 2 diabetes mellitus(T2DM group)and healthy people(health group)who were treated in the Affiliated Hospital of Guangdong Medical University from November 2013 to January 2020 were selected,with 101 in each group.The general information,NLR,PLR,MHR,blood glucose,blood lipids,blood uric acid,cystatin C and echocardiography(left ventricular diastolic function and ejection fraction),electrocardiogram(arrhythmia and ST-T changes)and other indicators in 3 groups were analyzed.Results Compared with healthy group,NLR and MHR in DCM group were significantly higher(H=19.982,11.607,all P<0.05);compared with T2DM group,PLR in DCM group was higher(H=9.969,P<0.05).Spearman correlation analysis showed that NLR was positively correlated with PLR(r=0.644,P<0.001).Logistic regression analysis showed that diastolic blood pressure,cystatin C,NLR and left ventricular diastolic function were risk factors for DCM(β=0.069,3.583,0.356,1.268,all P<0.01).For each unit increase of NLR,the risk of DCM was increased by 1.428 times.Conclusion Patients with DCM have higher levels of NLR,PLR,and MHR,and NLR is an independent risk factor for DCM.