血清asprosin与糖尿病视网膜病变的相关性研究

Association of serum asprosin concentrations with diabetic retinopathy

目的探讨糖尿病视网膜病变患者血清asprosin水平与糖尿病视网膜病变的相关性。方法纳入2018年10月—2019年4月在山东大学齐鲁医院内分泌科就诊的120例2型糖尿病患者(2型糖尿病组)和34名健康对照者(对照组)。糖尿病患者根据眼底检查结果分为无视网膜病变的糖尿病组(52例)、非增殖性糖尿病视网膜病变(NPDR)组(42例)和增殖性糖尿病视网膜病变(PDR)组(26例),测量身高、体重、血压。空腹8 h后抽取静脉血,检测血脂、糖化血红蛋白,酶联免疫吸附法检测血清asprosin水平。结果2型糖尿病组血清asprosin高于健康对照组,PDR组血清asprosin高于其他两组糖尿病患者,而NPDR组血清asprosin也明显高于无视网膜病变的糖尿病组(F=35.526,P=0.000)。Logistic回归分析显示,血清asprosin是糖尿病视网膜病变发病的独立危险因素(OR=1.268,95%CI:1.121~1.435,P=0.000)。结论糖尿病视网膜病变患者的血清asprosin升高,且asprosin升高是糖尿病视网膜病变的危险因素。

ed from all subjects after fasting for 8 hours.Then serum lipid and glycosylated hemoglobin were assessed.Serum asprosin levels were assessed using enzyme linked immunosorbent assay.Results Serum asprosin level was significantly higher in the diabetic groups than that in control group.Serum asprosin level was significantly increased in PDR group compared with the other two T2DM groups.In addition,compared with diabetic patients without diabetic retinopathy group,serum asprosin level was significantly increased in NPDR group(F=35.526,P=0.000).Logistic regression analysis demonstrated that serum asprosin was an independent risk factor of diabetic retinopathy(OR=1.268,95%CI:1.121-1.435,P=0.000).Conclusion Serum asprosin level is elevated in diabetic retinopathy patients.Serum asprosin is correlated with diabetic retinopathy.