相转移催化法制备对甲氧基苯甲酸

Preparation of P-Methoxybenzoic Acid by Phase Transfer Catalysis

对甲氧基苯甲酸又称为茴香酸,是一种医药和香料的中间体。传统工艺以对羟基苯甲酸和硫酸二甲酯为原料,在氢氧化钠为催化剂的条件下反应制得,生产过程中产生大量酸性废水。采用对甲基苯甲醚相转移催化剂制备对甲氧基苯甲酸,相比传统工艺更为环保、节约和高效。

P-Methoxybenzoic acid,also known as anisic acid,is an intermediate of medicine and spices.(Application)The traditional process uses p-hydroxybenzoic acid and dimethyl sulfate as raw materials,and is prepared by reacting with sodium hydroxide as a catalyst.A large amount of acidic wastewater is produced during the production process.In this paper,p-methylanisole phase transfer catalyst is used to prepare p-methoxybenzoic acid,which is more environmentally friendly,economical and efficient than traditional processes.