血清Fractalkine、Vaspin水平与重度子痫前期患者心功能关系

Correlation between serum Fractalkine and Vaspin levels and cardiac function of pregnant women with severe preeclampsia

目的:探讨血清不规则趋化因子(Fractalkine)、脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)水平与重度子痫前期患者心功能的相关性。方法:回顾性收集2016年1月—2019年7月本院门诊收治的重度子痫前期孕妇84例为观察组,产前检查正常妊娠孕妇50例为对照组。比较各组血清Fractalkine、Vaspin水平及心功能指标,并行Pearson相关性和多元线性回归分析。结果:观察组血清Fractalkine(402.57±78.69 pg/ml)高于对照组(153.27±76.53 pg/ml),Vaspin水平(6.27±1.48)低于对照组(7.32±2.13),左室射血分数(58.37±4.72)%、舒张早期最大流速(E峰)/舒张晚期最大流速(A峰)(0.71±0.21)低于对照组,Tei指数(0.57±0.04)高于对照组(均P<0.05)。经Pearson相关性分析,观察组Fractalkine与LVEF、E/A均呈负相关,与Tei指数呈正相关(P<0.05),Vaspin与LVEF、E/A均呈正相关,与Tei指数呈负相关(P<0.05)。经多元线性回归分析,Fractalkine、Vaspin是重度子痫前期患者心功能的独立影响因素。结论:血清Fractalkine、Vaspin与重度子痫前期患者心功能直接相关,有望成为临床诊治的参考指标。

Objective:To investigate the correlation between serum levels of irregular chemokines(Fractalkine)and fat-specific serine protease inhibitors(Vaspin)and cardiac function of pregnant women with severe preeclampsia.Methods:84 pregnant women with severe preeclampsia from January 2016 to July 2019 were selected retrospectively in observation group,and 50 normal pregnant women were selected in control group during the same period.The serum levels of Fractalkine and Vaspin,and cardiac function index of women were compared between the groups.Pearson correlation analysis and multiple linear regression analysis were performed.Results:The serum Fractalkine level(402.57±78.69 pg/ml)of women in the observation group was significant higher than that(153.27±76.53 pg/ml)of women in the control group,but the Vaspin level(6.27±1.48)of women in the observation group was significant lower than that(7.32±2.13)of women in the control group(P<0.05).The left ventricular ejection fraction(LVEF)value(58.37±4.72%)and E/A value(0.71±0.21)of women in the observation group were significant lower than those of women in the control group,but the Tei index value(0.57±0.04)of women in the observation group was significant higher(P<0.05).Pearson correlation analysis had showed that Fractalkine level was negatively correlated with the values of LVEF and E/A of women in the observation group,and was positively correlated with the Tei index value(P<0.05).The Vaspin level was positive with the values of LVEF and E/A of women in the observation group,and was negatively correlated with Tei index value(P<0.05).Multiple linear regression analysis had showed the levels of Fractalkine and Vaspin were independent factors affecting cardiac function of women with severe preeclampsia.Conclusion:Serum Fractalkine and Vaspin levels are directly related to cardiac function of women with severe preeclampsia,which are expected to be the reference indexes for clinical diagnosis and treatment of severe preeclampsia.