糖尿病肾病患者CD147的表达和意义

Expression and Clinical Significance of CD147 in Diabetic Nephropathy

目的:研究CD147在2型糖尿病肾病不同分期的表达,分析CD147与疾病进展的关系和意义。方法:选择2017年1月至2017年12月于陕西省人民医院肾病内科和内分泌科住院的2型糖尿病患者为研究组,根据糖尿病肾病的诊断标准分为微量白蛋白尿组(A组),大量白蛋白尿组(B组),肾功能损害组(C组),以及糖尿病正常白蛋白尿为对照组(D组),收集受试者的临床资料,采用ELISA方法检测各组研究对象的血清及尿液CD147、血清转化生长因子(transforming growth factor beta,TGF-β1)并进行对比分析。结果:A组、B组、C组的血清CD147,尿CD147逐渐升高,C组与A组、B、D组相比,有统计学显著性差异(P<0.05),B组与A组及D组相比,有统计学显著性差异(P<0.05)。C组血TGFβ1与A组、B组、D组相比,有统计学显著性差异(P<0.05)。糖尿病肾病患者血清CD147与尿CD147呈正相关关系,相关系数r为0.618(P<0.01),糖尿病肾病患者血清CD147与UACR呈正相关关系,相关系数r为0.503(P<0.01),与eGFR呈负相关关系,相关系数r为-0.557(P<0.05)。尿CD147水平与UACR呈正相关关系,相关系数r为0.425(P<0.01)与eGFR呈负相关关系,相关系数r为-0.312(P<0.05)。血TGFβ1水平与eGFR呈负相关关系,相关系数r为-0.22(P<0.05)。结论:CD147与糖尿病肾病进展有关,并对糖尿病肾病间质纤维化诊断具有一定的早期诊断价值。

Objective:To explore the expression and clinical significance of CD 147 in patient with type 2 diabetic nephropathy.Methods:Patients with type 2 diabetes who were hospitalized in the Department of Nephrology and Endocrinology of Shaanxi Provincial People's Hospital from January 2017 to December 2017 were selected as the study group.According to the diagnostic criteria of diabetic nephropathy,they were divided into the microalbuminuria group(Group A),The proteinuria group(group B),renal function impairment group(group C),and diabetic normal albuminuria were used as the control group(group D).The clinical data of the subjects were collected,and the serum and Urine CD147,TGF-β1 were compared.Result:Serum CD147 and urine CD147 gradually increased in groups A,B,and C.Compared with groups A,B,and D,there was a statistically significant difference in group C(P<0.05).Groups B and A and D There was a statistically significant difference between the groups(P<0.05).Compared with group A,group B and group D,TGFβ1 in group C had statistically significant differences(P<0.05).There was a positive correlation between serum CD147 and urine CD147 in patients with diabetic nephropathy,and the correlation coefficient r was 0.618(P<0.01).There was a positive correlation between serum CD147 and UACR in patients with diabetic nephropathy,and the correlation coefficient r was 0.503(P<0.01).The correlation coefficient r was-0.557(P<0.05).There was a positive correlation between urine CD147 level and UACR,with a correlation coefficient r of 0.425(P<0.01)and a negative correlation with eGFR,and the correlation coefficient r was-0.312(P<0.05).There was a negative correlation between blood TGFβ1 level and eGFR,and the correlation coefficient r was-0.22(P<0.05).Conclusion:CD147 may be related with DN progression and could be biomarkers of early stage diagnosis for DN interstitial fibrosis.