黄葵胶囊联合组合型人工肾对糖尿病肾病维持性血液透析患者炎性因子、氧化应激及生活质量的影响

Effect of Huangkui Capsule Combined with Combined Artificial Kidney on Inflammatory Factors,Oxidative Stress and Quality of Life in Maintenance Hemodialysis Patients with Diabetic Nephropathy

目的:探讨黄葵胶囊联合组合型人工肾对糖尿病肾病维持性血液透析患者炎性因子、氧化应激及生活质量的影响。方法:选取2018年10月~2019年9月我院收治的120例终末期糖尿病肾病维持性血液透析患者,将其按照随机数字表法分为观察组和对照组,各60例。两组患者均给予基础治疗,对照组采取组合型人工肾治疗。观察组在对照组基础上给予黄葵胶囊治疗。比较两组治疗3个月后的肾功能指标、炎性因子水平、氧化应激指标水平及生活质量,并统计不良反应发生情况。结果:治疗3个月后,两组血清尿素氮(BUN)、血清肌酐(Scr)、白蛋白排泄率(UAER)、超敏-C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、晚期氧化蛋白产物(AOPP)、丙二醛(MDA)水平低于治疗前,且观察组低于对照组(P<0.05)。两组过氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)水平及SF-36各维度评分均高于治疗前,且观察组高于对照组(P<0.05)。两组不良反应发生率比较无明显差异(P>0.05)。结论:黄葵胶囊联合组合型人工肾治疗终末期糖尿病肾病可有效减轻患者氧化应激及炎症反应,改善患者肾功能及生活质量,安全性高,具有较好的临床应用价值。

Objective:To explore the effect of Huangkui capsule combined with combined artificial kidney on inflammatory factors,oxidative stress and quality of life in maintenance hemodialysis patients with diabetic nephropathy.Methods:120 cases of maintenance hemodialysis patients with end-stage diabetic nephropathy in our hospital from October 2018 to September 2019 were selected.The patients were divided into observation group and control group according to the random number table method,60 cases in each group.Both groups were given basic treatment,the control group was treated with combined artificial kidney.On this basis of the control group,the observation group was given Huangkui capsule treatment.The renal function index,inflammatory factor level,oxidative stress index level and quality of life of the two groups were compared,the occurrence of adverse reactions was counted.Results:After 3 months of treatment,the serum urea nitrogen(BUN),serum creatinine(Scr),albumin excretion rate(UAER),hypersensitive C-reactive protein(hs-CRP),interleukin 6(IL-6),tumor necrosis factorα(TNF-α),advanced oxidation protein product(AOPP),malondialdehyde(MDA)levels in the two groups were lower than before treatment,and those in the observation group were lower than those in the control group(P<0.05).The of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and SF-36 levels in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Huangkui capsule combined with combined artificial kidney for end-stage diabetic nephropathy can effectively reduce the oxidative stress and inflammatory response,improve the renal function and quality of life of patients,it has a high safety,with better clinical application value.