甲花片对冠状动脉介入患者术后AKI的防治作用研究

Study on prevention and treatment effect of Jiahua Tablets on postoperative AKI in patients with coronary intervention

目的观察甲花片对冠状动脉介入(PCI)患者术后急性肾损伤(AKI)的防治作用。方法选取PCI治疗的80例患者为研究对象,分为治疗组、对照组,每组40例。对照组行PCI,治疗组在此基础上服用甲花片4片/次,每天3次。比较两组血肌酐(Scr)、尿素氮(BUN)、肾小球滤过率(eGFR)、白细胞介素(IL)-6、IL-8肾脏损伤因子的变化。结果治疗前两组各项指标比较,差异无统计学意义(P>0.05)。术后24 h治疗组IL-6、IL-8水平明显低于对照组(P<0.05);术后72 h治疗组Scr、BUN、IL-6、IL-8水平均明显低于对照组,而eGFR明显高于对照组(P<0.05)。与治疗前比较,术后24 h治疗组Scr、BUN水平升高,eGFR水平降低(P<0.05);与术后24 h比较,术后72 h治疗组Scr、BUN、IL-6、IL-8水平降低(P<0.05)。与治疗前比较,术后24 h对照组Scr、BUN、IL-6、IL-8水平明显升高,eGFR水平降低(P<0.05);与术后24 h比较,术后72 h对照组Scr、BUN、IL-6、IL-8水平升高,eGFR水平降低(P<0.05)。术后72 h治疗组与对照组造影剂肾病(CIN)的发病率比较(0 vs.12.5%),差异有统计学意义(P<0.05)。结论甲花片可用于PCI患者,其通过抑制炎性反应来保护和修复AKI。

Objective To observe the prevention and treatment effect of Jiahua Tablets on postoperative acute renal injury(AKI)in the patients with percutaneous coronary intervention(PCI).Methods A total of 80 patients treated by PCI were selected as the study subjects and divided into the treatment group and control group,40 cases in each group.The control group conducted PCI,while on this basis the treatment group took Jiahua Tablets,4 tablets per time,3 times a day.The changes of serum creatinine(Scr),urea nitrogen(BUN),glomerular filtration rate(eGFR),renal injury factors such as interleukin(IL)-6 and IL-8 were compared between the two groups.Results There was no statistically significant difference in the indicators before treatment between the two groups(P>0.05).The levels of IL-6 and IL-8 at postoperative 24 h in the treatment group were significantly lower than those in the control group(P<0.05);the levels of Scr,BUN,IL-6 and IL-8 at postoperative 72 h in the treatment group were significantly lower than those in the control group,while eGFR was significantly higher than that in the control group(P<0.05).Compared with before treatment,the levels of Scr and BUN at postoperative 24 h in the treatment group were increased,and the level of eGFR was decreased(P<0.05);compared with postoperative 24 h,the levels of Scr,BUN,IL-6 and IL-8 levels at postoperative 72 h were decreased(P<0.05).Compared with before treatment,the levels of Scr,BUN,IL-6,and IL-8 in the control group were significantly increased,while eGFR was decreased(P<0.05);compared with postoperative 24 h,the levels of Scr,BUN,IL-6 and IL-8 at postoperative 72 h in the control group were increased,while the eGFR level was decreased(P<0.05).There was statistically significant difference in the incidence rate of contrast-induced nephropathy(CIN)at postoperative 72 h between the treatment group and control group(0 vs.12.5%,P<0.05).Conclusion Jiahua Tablets can be used for the patients with PCI,which can protect and repair AKI by inhibiting the inflammatory response.