吸烟习惯对牙周炎患者牙龈液hBD-2、hBD-3及炎症因子水平表达的影响

Effects of smoking habits on expression levels of gingival fluid hBD-2,hBD-3 and inflammatory factors in patients with periodontitis

目的探讨吸烟习惯对牙周炎患者牙龈液β防御素2(hBD-2)、β防御素3(hBD-3)及炎症因子水平表达的影响。方法回顾性分析2018年1—12月海宁市中心医院收治的138例慢性牙周炎患者的临床病历资料,根据是否吸烟将纳入患者分为吸烟组(n=61)和非吸烟组(n=77),比较两组牙龈液hBD-2、hBD-3、内皮素-1(ET-1)、一氧化氮(NO)及炎症因子肿瘤坏死因子(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、白细胞介素-4(IL-4)、白细胞介素-5(IL-5)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平。结果吸烟组牙龈液hBD-2、hBD-3水平明显低于非吸烟组(P<0.05),ET-1、NO、hs-CRP、TNF-α、IL-1β、IL-4、IL-5、IL-6、IL-8水平明显高于非吸烟组(P<0.05);两组治疗后牙周临床指标均有所下降(P<0.05),吸烟组下降幅度明显小于非吸烟组(P<0.05)。结论吸烟会导致慢性牙周炎患者牙龈组织中炎症因子水平上升,加重炎性反应。

Objective To explore the effects of smoking habits on the expression levels of gingival fluidβdefensin 2(hBD-2),βdefensin 3(hBD-3)and inflammatory factors in the patients with periodontitis.Methods The clinical medical data of 138 patients with chronic periodontitis treated in the Haining Municipal Central Hospital from January to December 2018 were retrospectively analyzed.According to whether smoking,the patients were divided into the smoking group(n=61)and non smoking group(n=77).The levels of hBD-2,hBD-3,endothelin 1(ET-1),nitric oxide(NO),inflammatory factors such as tumor necrosis factorα(TNF-α),high sensitivity C reactive protein(hs-CRP),interleukin 1β(IL-1β),interleukin 4(IL-4),interleukin 5(IL-5),interleukin 6(IL-6)and interleukin 8(IL-8)in gingival fluid were compared between the two groups.Results The levels of gingival fluid hBD-2 and hBD-3 in the smoking group were significantly lower than those in the non-smoking group(P<0.05),while the levels of ET-1,NO,hs-CRP,TNF-α,IL-1β,IL-4,IL-5,IL-6 and IL-8 were significantly higher than those in the non-smoking group(P<0.05).After treatment,the periodontal clinical indexes in both groups were decreased(P<0.05),the decline amplitude in the smoking group was significantly smaller than that in the non-smoking group(P<0.05).Conclusion Smoking can increase the levels of inflammatory factors in gingival tissue of the patients with chronic periodontitis,and aggravates the inflammatory reactions.