摘要
P物质是一种进化保守的小分子活性肽,主要由神经元分泌,属于速激肽家族。P物质主要与G蛋白偶联受体家族的神经激肽-1受体结合,从而发挥多种生物学效应,包括痛觉传递、炎症及免疫调节等。目前研究发现,P物质及其受体神经激肽-1R(NK-1R)参与了肿瘤的演进过程,本文综述了P物质及其受体NK-1R与肿瘤最新的相关研究进展,揭示P物质及其受体NK-1R在恶性肿瘤发生、发展过程中的意义。
The substance P is an evolutionarily conserved small molecule active peptide which mainly secreted by neurons and belongs to the tachykinin family.The substance P mainly binds to the neurokinin 1 receptors which belong to the G protein coupled receptor family to exert a variety of biological effects,including pain transmission,inflammation and immune regulation and so on.The current studies have found that the substance P and its receptor NK-1R are involved in the evolution process of tumors.This paper reviews the latest related research progress of substance P and its receptor NK-1R with tumors and reveals the significance of substance P and its receptor NK-1R in the occurrence and development process of malignant tumors.
作者
张渝
杨昆(综述)
黄江菊(审校)
ZHANG Yu;YANG Kun;HUANG Jiangju(Department of Otolaryngology Head and Neck Surgery,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《重庆医学》
CAS
2020年第24期4194-4198,共5页
Chongqing medicine
基金
国家自然科学基金项目(81700895)。
