摘要
P44是嗜吞噬细胞无形体p44/msp2基因家族编码的膜表面含量最多、研究最广泛的蛋白。其作为一个穿孔蛋白广泛参与病原体感染早期的黏附、入侵、免疫逃逸及新陈代谢等多种复杂生理活动,与嗜吞噬细胞无形体的致病机制密切相关,已成为当下研究的热点分子。本文就该蛋白分子的主要生理功能、分子生物学特性等方面对其进行全面阐述。
P44 is the most widely studied protein encoded by p44/msp2 genes that is expressed on the membrane surface of Anaplasma phagocytophilum.It participates in many complex physiological activities,such as adhesion,invasion,immune escape and metabolism in early stages of infection.These functions are closely related to the pathogenesis of Anaplasma phagocytophilum and have been widely studied in recent research.In this review,the main physiological functions and molecular biological characteristics of P44 are systematically discussed.
作者
张秋宇
王峰
孙乐
陈施华
岳磊
严敏
ZHANG Qiu-Yu;WANG Feng;SUN Le;CHEN Shi-Hua;YUE Lei;YAN Min(Dept.of Pathogen Biology and Immunology,School of Basic Medicine,Kunming Medical University,Kunming 650500,China;Institute of Medical Biology,Chinese Academy of Medical Sciences,Kunming 650118,China)
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2020年第12期1038-1043,共6页
Chinese Journal of Zoonoses
基金
国家自然科学基金资助项目(No.31560271、No.81800012)
云南省科技计划项目省应用基础研究(昆医联合专项)基金资助项目[No.2017FE467(-124)、No.2017FE467(-125)、No.2019FE001(-017)]
云南省教育厅科学研究基金资助项目(No.2015C041Y)。
