系统性疾病胃肠道受累(一)

Gastrointestinal Involvement in Systemic Diseases:PartⅠ

消化系统是人体主要器官系统之一,诸多全身系统性疾病会直接或间接影响消化系统,随之产生相应的结构和功能改变。自身免疫性疾病是指机体对自身抗原发生免疫反应而导致的组织器官损害,胃肠道受累在结缔组织病、系统性血管炎、脊柱关节病、自身炎症性疾病中较为突出。肿瘤性疾病也可通过直接转移侵犯或副肿瘤综合征间接影响消化系统。本文重点介绍自身免疫性疾病和肿瘤性疾病对胃肠道的影响。

Digestive system is one of the major systems in human body.Many systemic diseases directly or indirectly affect the digestive system,resulting in corresponding structural and functional changes.Autoimmune diseases are the damages of organs caused by immune response to autoantigens.Involvement of gastrointestinal tract is prominent in connective tissue diseases,systemic vasculitis,spondyloarthropathy and autoinflammatory diseases.Oncologic diseases can also affect the digestive system through direct metastasis or indirect paraneoplastic syndrome.This article aimed to review the gastrointestinal involvement in autoimmune diseases and oncologic diseases.