摘要
克罗恩病(CD)是一种胃肠道慢性炎性肉芽肿性疾病。近年来,CD在全球的发病率呈逐渐升高趋势,但其具体发病机制尚未明确,揭示确切发病机制具有重要意义。已有研究证实,环境等因素导致的肠道微生态改变与CD的发生有关;同时,CD导致的人体内环境的改变亦能引起机体肠道微生态发生改变。调节肠道微生态对CD有治疗作用。本文就肠道微生态在CD中的作用和治疗展望作一综述。
Crohn’s disease(CD)is a chronic inflammatory granulomatous disease of gastrointestinal tract.The global incidence of CD increased in recent years,yet its pathogenesis has not yet been clarified,and it is of great significance to reveal the exact pathogenesis.It has been confirmed that changes of the intestinal microecology caused by environmental factors are correlated with the occurrence of CD;meanwhile,the changes of body’s internal environment caused by CD can cause changes in intestinal microecology.Regulation of intestinal microecology has therapeutic effect on CD.This article reviewed the role of intestinal microecology in CD and the prospect of treatment.
作者
李双
王轩
王晓艳
唐岸柳
LI Shuang;WANG Xuan;WANG Xiaoyan;TANG Anliu(Xiangya School of Medicine, Central South University, Changsha 410013;Department of Gastroenterology, the Third Xiangya Hospital of Central South University, Changsha)
出处
《胃肠病学》
2020年第7期431-435,共5页
Chinese Journal of Gastroenterology
基金
国家自然科学基金面上资助项目(81970494)。
关键词
肠道微生态
CROHN病
益生菌
粪菌移植
治疗
Intestinal Microecology
Crohn Disease
Probiotics
Fecal Microbiota Transplantation
Therapy
