椎旁神经阻滞辅助用药研究进展

Advances in the study of adjuvant drugs for thoracic paravertebral nerve block

椎旁神经阻滞(thoracic paravertebral block,TPVB)可在术后早期提供有效镇痛,且最近有研究表明局部麻醉药联合辅助药物的使用能够延长感觉或运动阻滞时间,改善患者术后疼痛评分。文章总结不同局部麻醉药佐剂在TPVB中应用时的临床效果、使用剂量、作用机制、安全性及有效性,有助于明确辅助药物在TPVB中使用的临床意义,同时也有助于找到合理的药物配伍及使用剂量,增强TPVB镇痛效果,延长镇痛持续时间,加速患者术后快速康复,为临床麻醉镇痛提供新的参考。

Thoracic paravertebral block(TPVB)can provide effective analgesia in the early postoperative period.Recent studies have shown that the use of local anesthetics combined with adjuvant drugs prolongs sensory or motor block time and improves post-operative pain scores.This article summarizes the clinical effects,dosages,mechanism of action,safety and effectiveness of different local anesthetic adjuvants when used in TPVB,which helps to clarify the clinical significance of adjuvant drugs used in TPVB.In the meantime,it is also helpful to find a reasonable drug compatibility and dosage,enhance the analgesic effect of TPVB,extend the duration of analgesia,and accelerate the rapid recovery of patients after surgery,providing a new reference for clinical anesthesia analgesia.