microRNAs在勃起功能障碍发生机制中的研究进展

Role of microRNAs in erectile dysfunction: An update

microRNAs(miRNAs)是一类由大约19~23个核苷酸组成的内源性非编码小分子RNA,其通过调控转录后的基因表达,参与多种病理和生理过程。勃起功能障碍(ED)是一种常见的男性性功能障碍,严重影响患者的生活质量,目前仍缺乏有效的临床治疗方法。迄今为止,越来越多的研究表明miRNAs在多种类型ED的发生及进展中发挥重要作用。本文就近年来miRNAs在ED发病机制中的研究进展进行综述。

MicroRNAs(miRNAs) are short non-coding RNAs consisting of approximately 19-23 nucleotides and involved in many pathological and physiological processes by regulating post-transcriptional gene expressions. ED is one of the common male sexual dysfunctions seriously affecting the patient’s quality of life, for which there is currently a lack of effective treatments clinically. More and more experiments have demonstrated that miRNAs are involved in the pathological process of different types of ED. This article presents an overview of the progress in the studies of the pathogenic role of miRNAs in ED. Natl J Androl, 2020, 26(10): 934-937.