2009-2019年浙江省温岭地区幽门螺杆菌耐药情况分析

Drug resistance of Helicobacter pylori in Wenling,Zhejiang,2009–2019

目的分析2009-2019年浙江省温岭地区不同年龄组人群幽门螺杆菌(HP)的耐药情况,为HP个体化治疗提供参考依据。方法收集2009-2019年浙江省温岭地区胃镜检查患者胃黏膜标本,分离HP菌株,进行阿莫西林、左氧氟沙星、克拉霉素及甲硝唑耐药性测定,并以每10岁为一个年龄组进行分层,分析HP在不同年龄组人群的耐药情况以及不同年龄组人群耐药率的变化趋势。结果共收集95 448例胃镜检查患者胃黏膜标本,HP分离株28 774株,温岭地区HP对阿莫西林、克拉霉素、左氧氟沙星、甲硝唑的平均耐药率为0.37%、23.52%、30.62%和3.61%。克拉霉素和左氧氟沙星的耐药率随着年龄增加而上升。20岁以下年龄组人群对甲硝唑、克拉霉素和左氧氟沙星的耐药率增速较其他年龄组快。结论温岭地区HP抗菌药物耐药情况较为严重,低、高年龄组人群HP耐药率增加显著,应重点关注。

Objective To analyze the drug resistance of Helicobacter pylori(H.pylori)in different age groups in Wenling,Zhejiang province, from 2009 to 2019, and provide reference for individualized treatment of H. pylori infection. Methods The gastric mucosal samples of patients undergoing gastroscopy from 2009 to 2019 were collected, H. pylori strains were isolated,and the strains’ drug resistances to amoxicillin, levofloxacin, clarithromycin and metronidazole were detected. The antibiotic resistance rates and trends of H. pylori in different age groups divided by 10 years old were analyzed. Results A total of95 448 gastric mucosal samples from patients undergoing gastroscopy were collected, in which 28 774 H. pylori strains were isolated. The average resistance rates of H. pylori to amoxicillin, clarithromycin, levofloxacin, and metronidazole in Wenling were 0.37%, 23.52%, 30.62% and 3.61%, respectively. The resistance rates to clarithromycin and levofloxacin increased with age. The resistance rate to metronidazole, clarithromycin and levofloxacin in people aged <20 years increased faster compared with other age groups. Conclusion The antibiotic resistance of H. pylori in Wenling was relatively serious, and the resistance rates in young and old age groups increased significantly, indicating that special attention should be paid to it.