重组人脑钠肽治疗急性心肌梗死急诊PCI患者的效果

Effects of Recombinant Human Brain Natriuretic Peptide in Treating Acute Myocardial Infarction Patients with Emergency PCI

目的探究重组人脑钠肽(recombinant human brain natriuretic peptide,rhBNP)对急性心肌梗死(acute myocardial infarction,AMI)行急诊皮冠状动脉介入术(PCI)治疗患者血清可溶性人基质裂解素2(soluble suppression of tumorigenicity 2,sST-2)、N末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNT)、Adropin蛋白的影响。方法选取AMI患者120例,按照随机数字表法分为观察组和对照组,各60例。2组均行急诊PCI,观察组于术前给予rhBNP治疗。比较2组疗效及治疗前后血清sST-2、NT-proBNP、Adropin蛋白水平和心功能。结果治疗前,观察组与对照组血清sST-2、NT-proBNP及Adropin蛋白比较,差异无统计学意义(P>0.05);治疗后,观察组血清sST-2为(16.47±4.54)μg·L^-1、NT-proBNP为(3285.12±603.08)ng·L^-1,低于对照组的(24.05±3.26)μg·L^-1、(3627.15±638.67)ng·L^-1;Adropin蛋白为(648.14±78.83)ng·L^-1,高于对照组的(582.15±72.86)ng·L^-1,差异均有统计学意义(P<0.05)。治疗后,2组左心室舒张末期内径(left ventricular end diastolic dimension,LVEDD)、左心室收缩末期内径(left ventricular end systolic diameter,LVESD)降低,左心室射血分数(left ventricular ejection fraction,LVEF)升高,且观察组变化幅度大于对照组,差异有统计学意义(P<0.05)。观察组临床治疗有效率为91.66%,高于对照组的83.33%,差异有统计学意义(P<0.05)。结论rhBNP治疗AMI行急诊PCI患者的效果明显,可有效降低患者血清sST-2、NT-proBNP水平,提高血清Adropin蛋白水平,改善心功能,为改善患者生存质量提供参考。

Objective To explore the effects of recombinant human brain netriuretic peptide(rhBNP)on acute myocardial infarction(AMI)in patients with acute myocardial infarction(AMI)undergoing percutaneous coronary intervention(PCI)in the treatment of serum soluble suppression of tumorigenicity 2(SST-2),N-terminal pro-brain natriuretic peptide(NT-proBNT),Adropin protein.Methods 120 AMI patients were divided into two groups according to random number table,60 cases in each group.Both groups were treated with PCI,while the patients in the observation group were treated with rhBNP before operation.The serum levels of sST-2,NT-proBNP,Adropin and cardiac function before and after treatment were compared,as well as the effects of the two groups.Results Before treatment,the sST-2,NT-proBNP,Adropin of observation group were compared with those of the control group.The differences were not statistically significant(P>0.05).After treatment,the sST-2 of observation group was(16.47±4.54)μg·L^-1,NT-proBNP(3285.12±603.08)ng·L^-1 were lower than those of control group(24.05±3.26)μg·L^-1、(3627.15±638.67)ng·L^-1,and Adropin(648.14±78.83)ng·L^-1were higher than that of control group(582.15±72.86)ng·L^-1,the differences were statistically significant(P<0.05).After treatment,the left ventricular end diastolic dimension(LVEDD)and left ventricular end systolic diameter(LVESD)significantly reduced in the two groups,while the left ventricular ejection fraction(LVEF)significantly increased.And the change amplitude of the observation group was larger than that of the control group,the difference was statistically significant(P<0.05).The effective rate of clinical treatment in the observation group was 91.66%was higher than that of the control group(83.33%).The difference was statistically significant(P<0.05).Conclusion The rhBNP treatment of AMI patients undergoing emergency PCI has an obvious therapeutic effect,which can effectively reduce the serum sST-2 and NT-proBNP levels,increase the serum Adropin protein level,and improve the cardiac function,which provides a reference for clinical improvement of the quality of life of patients.