生命早期经历饥荒与成年后2型糖尿病的相关性研究

Relationship between famine exposure in early life and type 2 diabetes mellitus in adulthood

目的探讨生命早期经历天灾饥荒与成年后2型糖尿病患病风险的相关性。方法本研究采用整群抽样的方法,纳入8868名出生于中国天灾饥荒期间(1959至1962)的上海市嘉定社区常住居民。研究对象分为未经历组、胎儿期经历组、儿童期经历组和青少年期经历组。采用logistic回归模型分析生命早期经历饥荒与成年后2型糖尿病风险的关系。结果女性在儿童期经历饥荒和青少年期经历饥荒均增加成年后患2型糖尿病的风险。在男性中并未观察到显著的相关性。在较少体育活动、较低文化水平人群中,饥荒经历组成年后罹患2型糖尿病的风险较未经历组显著增加,且具有显著的交互作用。结论生命早期经历饥荒增加成年后患2型糖尿病风险,尤其是在女性中。

Objective To investigate the correlation between exposure to famine in early life and later risk of type 2 diabetes in adulthood.Methods A cluster sampling method was used to include 8868 residents who were lived in the Jiading community of Shanghai during the Great Famine from 1959 to 1962 in China.Subjects were divided into non-exposed group,fetal exposure group,childhood exposure group,and adolescent exposure group.Logistic regression model was used to analyze the relationship between famine exposure in early life and the risk of type 2 diabetes in adulthood.Results Famine exposure during childhood and adolescent both increased the risk of developing type 2 diabetes in adulthood in women.No significant correlation was observed in men.In subjects with less physical activity and lower education level,the risk of developing type 2 diabetes mellitus in adulthood was significantly higher in the famine-exposed group than that of non-exposed groupand the interactions were statistically significant.Conclusion Early life famine exposure increases the risk of developing type 2 diabetes in adults,especially in women.