生命早期经历饥荒对绝经后女性超声骨密度的影响

Effects of famine exposure in early life on bone mineral density measured by ultrasound in postmenopausal women

目的探讨生命早期经历饥荒与绝经后女性超声骨密度的关系。方法2011年5月至2011年10月整群随机抽取贵阳市云岩区40岁以上的常住居民10140人,并对其随访3年,以随访人群7493人为研究对象,最终共纳入1504人。根据出生日期分组,分别比较各经历组与非经历组之间超声骨密度和骨质疏松患病风险的差异。结果婴幼儿期和学龄前期经历组的超声骨密度(SOS、T值、QUI)较非经历组明显减少(P<0.05)。非经历组、胎儿期、婴幼儿期、学龄前期经历饥荒组中高骨质疏松患病风险分别为50%、46.8%、58.4%、62.8%(P<0.01)。多重线性回归分析显示婴幼儿期和学龄前期经历饥荒与SOS、T值、QUI呈显著负相关,胎儿期经历与SOS、T值、QUI均无统计学意义。与非经历组相比,中高骨质疏松患病风险在婴幼儿和学龄前期经历饥荒组OR分别为(OR=1.41,95%CI 1.02~1.96)、(OR=1.68,95%CI 1.21~2.34),均有统计学意义(P<0.05),胎儿期经历组无统计学意义。调整混杂因素后,与非经历组相比,婴幼儿期和学龄前期经历饥荒组中高骨质疏松患病风险分别为1.64和1.90(OR=1.64,95%CI 1.16~2.32,P<0.05和OR=1.90,95%CI 1.35~2.70,P<0.05)。结论在绝经女性中,生命早期经历饥荒与超声骨密度(SOS、T值、QUI)呈显著负相关,与骨质疏松患病风险增加有关。

Objective To explore the relationship between famine exposure in early life and bone mineral density measured by ultrasound in postmenopausal women.Methods From May 2011 to October 2011,10140 residents over 40 years old in Yunyan District of Guiyang City were randomly selected,and followed up for 3 years,7493 subjects were selected and finally included a total of 1504 subjects.Grouped by date of birth,the differences in bone mineral density measured by ultrasound,and risk of osteoporosis between the exposed and non-exposed groups were compared.Results SOS,T-score,and QUI in infant-and preschool-exposed group were lower than those of non-exposed group.The medium/high risk of osteoporosis in non-exposed,fetal-exposed,infant-exposed,and preschool-exposed groups were 50%,46.8%,58.4%,and 62.8%,respectively(P<0.01).Multivariate linear regression analysis showed that famine exposure in infant-and preschool-exposed groups were significantly negative correlated with SOS,T-score,and QUI,while fetal-exposed group was not significantly correlated with SOS,T-score,and QUI.Compared with the non-exposed group,the OR of the medium/high risk of osteoporosis in the infant-and preschool-exposed groups were(OR=1.41,95%CI 1.02-1.96)、(OR=1.68,95%CI 1.21-2.34),with statistically significance(P<0.05),and there was no statistical significance in the fetal-exposed group.After adjusting for confounding factors,the medium/high risk of osteoporosis in infant-and preschool-exposed group were 1.64 and 1.90 as compared with the non-exposed group(OR=1.64,95%CI 1.16-2.32,P<0.05 and OR=1.90,95%CI 1.35-2.70,P<0.05).Conclusion In postmenopausal women,famine exposure in early life was significantly negatively correlated with bone mineral density measured by ultrasound(SOS,T-score,and QUI),and was associated with an increased risk of osteoporosis.