生命早期营养不良与成年后糖脂代谢疾病的关系

Malnutrition in early life and metabolic diseases in adulthood

全世界糖尿病和肥胖等糖脂代谢疾病的患病率在不断升高,而中国人群患病率上升速度尤为迅猛,糖脂代谢疾病已成为我国重大公共卫生问题,一级预防显得尤为迫切。DOHaD(Developmental Origin of Health and Diseases)理论提出生命早期的环境因素如营养会影响某些成人非传染性疾病特别是代谢疾病的发生风险。由于我国经济发展的不平衡,生命周期营养失衡(如生命早期营养不良和成年营养过剩)仍旧是普遍存在的问题。国内外最近有较多学者对饥荒下生命早期营养不良环境和成年后糖脂代谢疾病发生发展的关系进行了多方面和深入的研究,本文对这一领域作一综述,并提出生命早期营养不良成年后营养过剩(两次打击)营养代谢模型。这些研究将为中国、印度等经济快速发展的发展中国家预防糖脂代谢疾病提供科学依据。

The prevalence of metabolic diseases,such as type 2 diabetes mellitus and obesity,is increasing all over the world.Metabolic diseases have become a major public health problem in China,and primary prevention is particularly important and urgent.According to the theory of DOHaD(Developmental Origin of Health and Diseases),negative environmental factors in early life,such as malnutrition,may increase the risk of some non-communicable diseases,especially metabolic diseases in adulthood.Due to regional economic development disparities in China,life cycle nutrition imbalance(such as malnutrition in early life and overnutrition in adults)is still a common problem.Recently,many scholars have made comprehensive and in-depth studies on the relationship between malnutrition in early life and the development of metabolic diseases in adulthood.This paper summarizes the recent results in this field and puts forward a metabolic model of undernutrition in early life and overnutrition in adulthood(double burden theory).These studies will provide related evidence for the prevention of metabolic diseases in rapidly developing countries such as China and India.