特布他林联合盐酸氨溴索注射液治疗小儿重症肺炎的疗效观察

Efficacy of terbutaline combined with ambroxol hydrochloride injection in the treatment of severe pneumonia in children

目的探讨特布他林联合盐酸氨溴索注射液治疗小儿重症肺炎的疗效。方法选取2017年10月~2019年10月收治的重症肺炎患儿80例,采取随机数表法分为对照组(40例)与研究组(40例),所有患者均采取常规治疗,对照组患者在常规治疗基础上予盐酸氨溴索注射液治疗,研究组患者在对照组基础上予特布他林辅助治疗,连续治疗1周。比较两组疗效,治疗前后炎性指标[降钙素原(PCT)水平、C反应蛋白(CRP)、白细胞(WBC)计数]与各临床症状、体征消失时间、住院时间及治疗期间不良反应率。结果研究组治疗总有效率92.50%显著高于对照组75.00%(χ~2=4.50,P=0.03);治疗后两组PCT水平、CRP水平、WBC计数均明显下降,且研究组PCT水平、CRP水平、WBC计数明显低于对照组(P<0.05);研究组气促缓解、止咳、热退、啰音消失、住院时间均明显低于对照组(P <0.05);研究组治疗期间不良反应率12.50%与对照组不良反应发生率10.00%比较,差异无统计学意义(χ~2=0.13,P=0.72)。结论对重症肺炎患儿采取特布他林联合盐酸氨溴索注射液治疗效果显著,可有效改善患儿炎症反应与临床症状,缩短病程,且不良反应少,安全性高。

Objective To explore the efficacy of terbutaline combined with ambroxol hydrochloride injection in the treatment of severe pneumonia in children.Methods 80 children with severe pneumonia admitted to our hospital from October 2017 to October 2019 were randomly divided into the control group(40 cases)and the study group(40 cases).All patients were treated with routine treatment.The control group was treated with ambroxol hydrochloride injection on the basis of routine treatment.The study group was treated with terbutaline on the basis of the control group for one week.Before and after treatment,the inflammatory indexes(PCT level,CRP,WBC)were compared with the clinical symptoms,disappearance time of physical signs,hospitalization time and adverse reaction rate during treatment.Results The total effective rate of the study group was 92.50%,which was significantly higher than that of the control group(χ2=4.50,P=0.03);after treatment,the PCT level,CRP level and WBC count of the two groups were significantly decreased,and the PCT level,CRP level and WBC count of the study group were significantly lower than those of the control group(P<0.05);the gas promoting remission,cough stopping,fever regression,rale disappearance and hospitalization time of the study group were significantly lower than those of the control group(P<0.05);There was no significant difference between the study group and the control group(χ2=0.13,P=0.72).Conclusion The therapeutic effect of terbutaline combined with ambroxol hydrochloride injection on children with severe pneumonia is significant,which can effectively improve the inflammatory reaction and clinical symptoms,shorten the course of disease,and has less adverse reactions,high safety.