摘要
Understanding the development,regeneration,and disorders of the liver is the major goal in liver biology.Current mechanistic knowledge of human livers has been largely derived from mouse models and cell lines,which fall short in recapitulating the features of human liver cells or the structures and functions of human livers.Organoids as an in vitro system hold the promise to generate organ-like tissues in a dish.Recent advances in human liver organoids also facilitate the understanding of the biology and diseases in this complex organ.Here we review the progress in human liver organoids,mainly focusing on the methods to generate liver organoids,their applications,and possible future directions.
基金
This study is supported by the Chinese Academy of Sciences(XDA16020201 and XDA12050104)
the National Science and Technology Major Project*Key New Drug Creation and Manufacturing Program,(2018ZX09711002-009).
