摘要
利用多组分一锅法反应,在微波照射条件下简便快速合成一系列2-氨基-6-(3-吲哚基)-4-芳基-4H-吡喃-3,5-二腈化合物,并对目标产物进行了熔点、红外、核磁共振谱以及X-射线单晶衍射表征。2-氨基-4-(3-硝基苯基)-6-(1H-吲哚-3-基)-4H-吡喃-3,5-二腈单晶衍射结果表明:该晶体属于三斜晶系,空间群P-1,晶体参数为a=0.9492(2)nm、b=1.1417(3)nm、c=1.2040(3)nm、α=105.061(2)°、β=103.199(3)°、γ=111.188(3)°。在分子晶体结构中,新构建的吡喃环为平面构型,其与相连的吲哚环接近平行,其二面角为7.33(4)°,其与相连的芳环接近垂直构型,其二面角为87.89(4)°。
A serial of indole-pyran heterocycles derivatives,2-amino-4-aryl-6-(1H-indol-3-yl)-4H-pyran-3,5-dicarbonitrile,were synthesized by microwave-assistant one-pot three-component reaction and fully characterized by IR,~1HNMR and single X-ray diffraction.The crystal of 2-amino-4-(3-nitrophenyl)-6-(1H-indol-3-yl)-4H-pyran-3,5-dicarbonitrile belongs to triclinic,space group P-1 with a=0.9492(2)nm,b=1.1417(3)nm,c=1.2040(3)nm,α=105.061(2)°,β=103.199(3)°,γ=111.188(3)°.In the crystal structure,the pyran ring adopts plane configuration,which linked with the indole ring for almost coplanar conformation with dihedral angle 7.33(4)°.The pyran ring and attached benzene ring have nearly vertical conformation with the dihedral angle is 87.89(4)°.
作者
於露
龚潘伟
马莹
朱松磊
YU Lu;GONG Pan-wei;MA Ying;ZHU Song-lei(School of Basic Medical Sciences,Xuzhou Medical University,Xuzhou 221004,China;School of Pharmacy,Xuzhou Medical University,Xuzhou 221004,China)
出处
《化学试剂》
CAS
北大核心
2020年第11期1355-1360,共6页
Chemical Reagents
关键词
吲哚-3-基吡喃
多组分反应
微波反应
晶体结构
合成
indol-3-yl-pyran
multi-component reaction
microwave reaction
crystal structure
synthesis