牙龈卟啉单胞菌靶向细胞膜运输的研究进展

Advances in Porphyromonas gingivalis Targeted Cell Membrane Transport

牙龈卟啉单胞菌(Pg)与食管鳞状细胞癌的发生和发展有关,被认为是食管鳞癌的高危因素。Pg是革兰氏阴性厌氧杆菌,具有很强的细胞侵入能力。有研究表明,Pg可利用膜运输途径进入细胞,并在宿主细胞体内长期存活。实际上,细胞内病原体已经进化出多种策略来操纵其宿主细胞,以使自己在不利环境中生存和复制。它们经常利用膜运输途径进入细胞,建立一个复制的微环境,避免被降解和免疫清除,获取营养,最后逃逸。在最近关于膜运输细胞内病原体的研究中,发现了非规范机制的泛素化和新颖的自噬受体。研究病原体如何靶向宿主细胞膜转运途径,不仅有助于理解细胞生物学的基本机制,而且对开发新的治疗方法也很重要。

Porphyromonas gingivalis(Pg)is associated with the occurrence and development of esophageal squamous cell carcinoma and is considered as a high risk factor for esophageal squamous cell carcinoma.Pg is a gram-negative anaerobic bacterium.It has a strong cell invasion ability.Studies have shown that Pg can enter cells by membrane transport,thus achieving long-term survival in host cells.In practice,intracellular pathogens have evolved a variety of strategies to manipulate their host cells to enable themselves to survive and replicate in adverse environments.They often use membrane transport pathways to enter cells and establish a replicated microenvironment to avoid degradation and immune responses,to get nutrients and to escape finally.In recent studies on pathogens in membrane-transported cells,ubiquitination and novel autophagy receptors with irregular mechanisms have been identified.The study of how pathogens target host cell membrane transport pathways is not only important for the development of new treatments,but also helps understand the basic mechanisms of cell biology.