牙龈卟啉单胞菌与细胞自噬相互作用研究进展

Research Progress in the Interaction between Porphyromonas gingivalis and Cell Autophagy

细菌侵入细胞后转入自噬小体是细菌躲避宿主细胞的降解,引发自噬逃逸的一种重要途径。牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)是引起牙周炎和食管炎的重要致病菌。Pg侵入细胞后,通过对内源性转运以及自噬过程的修饰调节,使得内源性转运或自噬过程无法正常进行,从而逃逸宿主细胞的降解作用,同时在被修饰后的自噬小体中创造一个适宜细菌定植、增殖的微环境。本文综述Pg自噬逃逸、定植增殖过程的生物化学和形态学特征,分析Pg胞内定植增殖的机制。

That the bacteria transform into autophagosomes after their invading the cells is an important way for them to avoid degradation of host cells and induce autophagy escape.Porphyromonas gingivalis(Pg)is an important pathogen causing periodontitis and esophagitis.After the Pg invades the cells,the endogenous transport or autophagy process cannot be carried out normally through endogenous transport and modifying the regulation of autophagy process,so,the Pg could escape the degradation of host cells,and create a microenvironment suitable for their colonization and proliferation in the modified autophagosome.This paper reviews the biochemical and morphological characteristics of Pg autophagy escape,colonization and proliferation,and analyzes the mechanism of Pg intracellular colonization and proliferation.