食管癌再程放疗疗效观察

Efficacy of Radiotherapy for Recurrent Esophageal Cancer after Initial Radiotherapy

目的探讨根治性放疗后局部复发食管癌再程放射治疗的疗效及毒性。方法收集我院2010年1月至2017年12月行根治性放疗后局部复发食管癌患者共67例,其中再程放射治疗患者40例为观察组,姑息治疗患者27例为对照组。采用Kaplan-Meier法计算各组生存率,组间生存差异的比较采用Log-rank检验。结果观察组复发后中位生存时间8个月,0.5、1 a生存率分别为57.5%、36.3%;对照组复发后中位生存时间为5个月,0.5、1 a生存率分别为43.3%、8.7%。复发时间与放疗剂量是独立预后因素,≥50 Gy生存获益较明显(P<0.05)。结论食管癌再程放疗可延长生存期,放射治疗副反应可接受。

Objective To evaluate the therapeutic efficacy and toxicity of radiation therapy for patients with loco-regional recurrent esophageal cancer after initial definitive radiotherapy.Methods 67 patients with loco-regional recurrent esophageal cancer underwent radical radiotherapy in PLA 989 Hospital were collected,from January 2010 to December 2017.40 patients with radiotherapy were in the observation group and 27 patients with palliative treatment were in the control group.Kaplan-Meier method was used to analyze the survival,Log-rank test was used to compared difference between groups.Results The median survival time after recurrence of observation group is 8 months,the median survival time in the control group is 5 months.The 0.5 and 1 year survival rate after recurrence was 57.5%and 36.3%,respectively,in the observation group,and 43.3%,8.7%in the control group.Recurrence time and the dose of radiotherapy were independent factors of survival,≥50 Gy could generate more favorable survival(P<0.05).Conclusion Radiation therapy for patients with loco-regional recurrent patients can improve survival,the side effects of radiotherapy are acceptable.