布地奈德联合特布他林雾化吸入治疗对毛细支气管炎患儿潮气呼吸肺功能、T细胞亚群及血清炎性因子的影响

Effects of Budesonide Combined with Terbutaline Inhalation on Tidal Breathing Pulmonary Function, T Cell Subsets and Serum Inflammatory Factors in Children with Bronchiolitis

目的:探讨布地奈德联合特布他林雾化吸入治疗对毛细支气管炎患儿潮气呼吸肺功能、T细胞亚群及血清炎性因子的影响。方法:选取2019年1月~2019年12月期间我院收治的毛细支气管炎患儿98例,采用随机数字表法分为对照组(常规方案治疗)和观察组(对照组基础上加用布地奈德联合特布他林雾化吸入治疗),各49例。记录两组治疗1周后总有效率。对比两组治疗前、治疗1周后的潮气呼吸肺功能指标[吸气/呼气时间比(Ti/Te)、达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)、每千克潮气量(Vt/kg)]、T细胞亚群[CD3^+、CD4^+、CD8^+及CD4^+/CD8^+]、血清炎性因子[降钙素原(PCT)、C反应蛋白(CRP)]。比较两组不良反应发生率。结果:观察组治疗1周后的总有效率为91.84%(45/49)高于对照组的69.39%(34/49),差异有统计学意义(P<0.05)。两组患儿治疗1周后Ti/Te、TPTEF/TE、VPEF/VE、Vt/kg、CD3^+、CD4^+、CD4^+/CD8^+均高于治疗前,且观察组高于对照组(P<0.05),PCT、CRP、CD8^+均低于治疗前,且观察组低于对照组(P<0.05)。两组患儿不良反应发生率对比无统计学差异(P>0.05)。结论:雾化吸入特布他林联合布地奈德治疗毛细支气管炎患儿疗效显著,可有效改善患儿T细胞亚群、潮气呼吸肺功能,减轻患儿炎性反应,且安全性好。

Objective: To investigate the effect of budesonide combined with terbutaline inhalation on tidal breathing pulmonary function, T cell subsets and serum inflammatory factors in children with bronchiolitis. Methods: 98 children with bronchiolitis in our hospital from January 2019 to December 2019 were selected, and they were randomly divided into control group(conventional treatment)and observation group(budesonide combined with terbutaline inhalation on the basis of the control group), 49 cases in each group. The total effective rate of the two groups 1 week after treatment was recorded. The indexes of tidal breathing pulmonary function [inspiratory/expiratory time ratio(Ti/TE), time to peak ratio(tptef/TE), peak volume ratio(VPEF/VE), tidal volume per kilogram(VT/kg)], T cell subsets [CD3^+, CD4^+, CD8^+and CD4^+/CD8^+], serum inflammatory factors [procalcitonin(PCT), C-reactive protein(CRP)] were compared between the two groups before and 1 week after treatment. The incidence of adverse reactions was compared between the two groups.Results: The total effective rate of the observation group was 91.84%(45/49), which was higher than 69.39%(34/49) of the control group1 week after treatment, and the difference was statistically significant(P<0.05). 1 week after treatment, Ti/Te, TPTEF/TE, VPEF/VE,Vt/kg, CD3^+, CD4^+, CD4^+/CD8^+of the two groups were higher than those before treatment, and the observation group was higher than the control group(P<0.05), PCT, CRP, CD8^+were lower than before treatment, and the observation group was lower than the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Budesonide combined with terbutaline aerosol inhalation in the treatment of children with bronchiolitis has significant curative effect, can play a synergistic role, improve the tidal breathing lung function effectively and T cell subsets, reduce the inflammatory reaction of children,and has good safety.