中西医结合治疗膜性肾病的疗效及机制研究

Efficacy and Mechanism of Integrated Traditional Chinese and Western Medicine in Membranous Nephropathy

目的:探究中西医结合对膜性肾病的治疗效果,并就其机制进行研究。方法:选择2015年12月至2019年12月于我院接受治疗的98例肾病综合征患者,按照随机数字表法将其均分为研究组与对照组(每组各49例),对照组接受常规西医治疗,研究组在对照组基础上加用中医疗法,对比两组治疗有效率,分别检测并对比治疗前后两组免疫球蛋白A(immunoglobulin A,Ig A)、免疫球蛋白G(immunoglobulin G,Ig G)、免疫球蛋白M(immunoglobulin M,Ig M)、蛋白排泄率(urinary albumin excretion rates,UAER)、血浆白蛋白(albumin,Alb)、尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,Scr)等指标,并就治疗安全性进行对比。结果:(1)研究组治疗有效率显著高于对照组(95.92%vs.81.63%,P<0.05);(2)治疗前两组Ig A、Ig G、Ig M水平对比无统计学意义(P>0.05),干预后研究组上述指标均优于对照组(P<0.05);(3)治疗前两组UAER、Alb、BUN及Scr水平对比无统计学意义(P>0.05),治疗后研究组上述指标均优于对照组(P<0.05);(4)研究组治疗中不良反应发生率低于对照组(P<0.05)。结论:中西医结合疗法对膜性肾病具有较好的治疗效果,能够显著改善患者免疫功能及肝肾功能,同时还能够降低治疗中不良反应发生率。

Objective:To explore the therapeutic effect of integrated traditional Chinese and western medicine on membranous nephropathy and to study its mechanism.Methods:98 patients with membranous nephropathy who were treated in our hospital from December 2015 to December 2019 were selected,and they were divided into study group and control group(49 patients in each group)according to the random number table method.The control group received conventional Western medicine treatment,and the study group were treated with traditional Chinese medicine on the basis of the control group.Compare the treatment effectiveness of the two groups,measure and compare Ig A,Ig G,Ig M,UAER,Alb,BUN,Scr and other indicators before and after treatment,and compare the safety.Results:(1)The treatment efficiency of the study group was significantly higher than that of the control group(95.92%vs.81.63%,P<0.05).(2)The levels of Ig A,Ig G,and Ig M in the two groups before treatment were not statistically significant(P>0.05).The above indicators in the study group were better than those in the control group after intervention(P<0.05).(3)The levels of UAER,Alb,BUN and Scr in the two groups before treatment were not statistically significant(P>0.05).The above indicators in the study group were better than those in the control group after treatment(P<0.05).(4)The incidence of adverse reactions in the treatment group was lower than that in the control group(P<0.05).Conclusion:The integrated Chinese and western medicine therapy has a good therapeutic effect on membranous nephropathy,which can significantly improve the immune function and liver and kidney function of patients,and can also reduce the incidence of adverse reactions during treatment.