摘要
二氢乳清酸脱氢酶是黄素依赖的线粒体酶,它催化嘧啶从头合成的第4步反应,将二氢乳清酸氧化为乳清酸。通过选择性抑制二氢乳清酸脱氢酶,从而抑制嘧啶的合成,已被开发用于治疗癌症、自身免疫性疾病、细菌或病毒感染以及寄生虫疾病等。抑制剂的开发需详细了解二氢乳清酸脱氢酶的结构特征和催化循环机制。因此,文中主要从这两个方面进行了综述,并展望了该酶的抑制剂在临床应用中的前景。
Dihydroorotate dehydrogenase is a flavin-dependent mitochondrial enzyme to catalyze the fourth step of the de novo synthesis of pyrimidine and to oxidize dihydroorotate to orotate.By selectively inhibiting dihydroorotate dehydrogenase,thereby inhibiting pyrimidine synthesis,the enzyme has been developed for the treatment of cancer,autoimmune diseases,bacterial or viral infections,parasitic diseases and so on.The development of inhibitory drugs requires a detailed understanding of the structural characteristics and catalytic cycle mechanism of dihydroorotate dehydrogenase.Therefore,this paper reviews these two aspects,and indicates perspectives of these inhibitors in clinical application.
作者
任小利
罗芬
李希希
易莎
杨兵
江志勇
Xiaoli Ren;Fen Luo;Xixi Li;Sha Yi;Bing Yang;Zhiyong Jiang(Food and Drug Teaching and Research Department,School of Environment and Quality Testing,Chongqing Chemical Industry Vocational College,Chongqing 401228,China;Research Institute of Surgery and Daping Hospital,Third Military Medical University,Chongqing 400042,China)
出处
《生物工程学报》
CAS
CSCD
北大核心
2020年第12期2732-2740,共9页
Chinese Journal of Biotechnology
基金
重庆市教育委员会科学技术研究项目(No.KJQN202004503)资助。
关键词
二氢乳清酸脱氢酶
结构特征
催化循环
类风湿性关节炎
新型冠状病毒
dihydroorotate dehydrogenase
structure characteristics
catalytic cycle
rheumatoid arthritis
novel coronavirus