人表皮生长因子的研究进展

Progress in human epidermal growth factor research

人表皮生长因子是激活表皮生长因子受体的生长因子家族的典型成员,由人体的多个组织器官合成与分泌,通过结合受体激活一系列信号途径,调控细胞的增殖、分化和迁移等。近年来,有关人表皮生长因子的研究已扩展到其在人类生理和病理作用的领域,尤其在组织再生和伤口愈合方面成为研究热点。文中综述了人表皮生长因子的研究进展,简要描述了其基因和蛋白的结构与特点、作用机制与生物学效应,重点介绍该生长因子在胃肠溃疡愈合、皮肤伤口修复和肿瘤病理过程中的作用与影响,从而为相关研究提供辅助信息。

Human epidermal growth factor(hEGF)is a typical member of the growth factor family that activates epidermal growth factor receptors.It is synthesized and secreted by multiple tissues and organs of the human body,regulating the cell proliferation,differentiation and migration via binding to receptors and activating a series of signaling pathways.In recent years,the research on hEGF has been extended to its role in human physiology and pathology,especially in tissue regeneration and wound healing.This paper reviews the research progress of hEGF,briefly describes its gene and protein structure and characteristics,mechanisms and biological effects,with the emphasis on the roles and influences in the healing of gastrointestinal ulcers,skin wound repair and tumor pathology.