CENPM表达在肝移植术后肝癌复发患者中的临床意义

Clinical significance of CENPM expression in patients with recurrent liver cancer after liver transplantation

目的研究促肝癌基因着丝粒蛋白M(CENPM)在肝移植术后肝癌复发患者中表达与临床特征的相关性以及对预后的影响。方法纳入肝移植术后肝癌复发患者82例,未复发组40例,对切除肝标本进行免疫组织化学染色观察CENPM表达水平,收集患者临床资料及预后情况,分析高表达组与低表达组临床特征、复发特征和预后的差异。结果复发患者82例中位随访时间为22(8~38)个月,CENPM高表达比例为70.7%,而未复发组为50.0%,差异有统计学意义(P=0.025)。复发患者中,高表达组与低表达组相比,无疾病生存时间差异有统计学意义(P=0.036);高表达组总体生存时间低于低表达组,差异有统计学意义(P=0.019)。结论CENPM表达与肝移植术后肝癌较快复发及转移有关,并影响患者预后。

Objective To study the correlation between the expression of the liver cancer-promoting gene centromere protein M(CENPM)in patients with recurrent liver cancer after liver transplantation and the clinical characteristics and its influence on the prognosis.Methods Eighty-two patients with recurrent liver cancer after liver transplantation and 40 patients without recurrence(the nonrecurrent group)were enrolled in the study.The expression of CENPM was detected by immunohistochemical staining in the resected liver specimens.The clinical data and prognosis of the patients were collected.The differences in clinical features,recurrence characteristics and prognosis between the high expression group and the low expression group were analyzed.Results The median follow-up time of the 82 patients with recurrent liver cancer was 22(8~38)months.The high expression ratio of CENPM was 70.7%in the 82 patients with recurrent liver cancer,and 50.0%in the nonrecurrent group,and the difference was statistically significant(P=0.025).In the patients with recurrence,the difference in disease-free survival time between the high expression group and the low expression group was statistically significant(P=0.036),and the overall survival time of the high expression group was significantly lower than that of the low expression group(P=0.019).ConclusionThe expression of CENPM is related to the faster recurrence and metastasis of liver cancer after liver transplantation and affects the prognosis of the patients.