慢性精神分裂症患者脑结构异常的MRI线性测量研究

Magnetic resonance imaging linear measurement of abnormal brain structure in patients with chronic schizophrenia

目的探究慢性精神分裂症患者的脑结构异常情况。方法选取自贡市精神卫生中心2017-01~2019-08收治的50例慢性精神分裂症患者作为研究组,另选择50名健康志愿者作为对照组,均行脑部磁共振成像(MRI)扫描。采用线性测量法测量第三脑室宽度、尾状核头部宽度、脑室前角间距、三角区域间距、外侧裂宽度、海马高度、胼胝体厚度等指标,并进行组间比较。结果研究组第三脑室宽度、左侧尾状核头部宽度、右侧尾状核头部宽度、左侧外侧裂宽度、右侧外侧裂宽度显著大于对照组(P<0.05)。两组在脑室前角间距、三角区域间距、左侧海马高度、右侧海马高度及胼胝体厚度方面比较差异无统计学意义(P>0.05)。结论慢性精神分裂症患者存在脑结构异常,MRI线性测量对慢性精神分裂症的诊断和鉴别诊断有一定意义。

Objective To explore the abnormalities of brain structure in patients with chronic schizophrenia.Methods Fifty patients with chronic schizophrenia admitted to Zigong Mental Health Center from January 2017 to August 2019 were selected as the research group,and other 50 healthy volunteers were selected as the control group.Both groups underwent brain magnetic resonance imaging(MRI)scans.The width of the third ventricle,the width of the head of the caudate nucleus,the distance between the anterior angles of the ventricle,the distance between the triangular regions,the width of the bilateral lateral fissure,the height of the hippocampus,the thickness of the corpus callosum and other indicators were measured by linear measurement method,and were compared between the two groups.Results The width of the third ventricle,the width of the head of the left caudate nucleus,the width of the head of the right caudate nucleus,the width of the left lateral fissure,and the width of the right lateral fissure in the research group were significantly larger than those in the control group(P<0.05).There were no significant differences between the two groups in the distance between the anterior angles of the ventricle,the distance between the triangular regions,the height of the left hippocampus,the height of the right hippocampus,and the thickness of the corpus callosum(P>0.05).Conclusion There are brain structural abnormalities in the patients with chronic schizophrenia.MRI linear measurement has certain significance for the diagnosis and differential diagnosis of chronic schizophrenia.