腹膜播散性平滑肌瘤病4例临床病理学特征分析及文献复习

Leiomyomatosis peritonealis disseminata:a clinicopathological feature analysis of 4 cases and review of literatures

目的探讨腹膜播散性平滑肌瘤病(LPD)的临床病理学特征、诊断及鉴别诊断。方法回顾性分析4例LPD患者的临床病理学特征、组织学形态及免疫表型并复习相关文献。结果4例均为女性,年龄32~51岁。镜检:肿瘤由梭形细胞组成,呈编织状排列,胞浆红染,核呈杆状,细胞大小较一致,无核分裂象。免疫表型:瘤细胞表达平滑肌肌动蛋白(SMA)、结蛋白(desmin)、Ki-67,而CD117、CD34、S-100、DOG-1均为阴性。结论LPD是一种罕见的良性肿瘤,预后良好,诊断主要依赖其组织病理学特征及免疫表型。

Objective To investigate the clinicopathological features,diagnosis and differential diagnosis of leiomyomatosis peritonealis disseminata(LPD).Methods The clinicopathological features,histological morphology and immunophenotype of 4 patients with LPD were retrospectively analyzed and the relevant literatures were reviewed.Results All of the 4 cases were female,aged 32~51 years.Microscopy:The tumors were consisted of relatively uniform spindle cells in an interlacing arrangement,cytoplasmic red staining,rod-shaped nuclei and rare mitosis.Immunophenotype:The tumor cells expressed smooth muscle actin(SMA),desmin and Ki-67,while CD117,CD34,S-100 and DOG-1 were all negative.Conclusion LPD is a rare benign tumor with a good prognosis.Its diagnosis mainly depends on its histopathological characteristics and immunophenotype.