壳聚糖表面改性钛合金材料的研究进展

Research advance in surface modification of titanium alloys with chitosan

钛合金材料生物性能良好,是骨科常用的内植入材料,但其骨整合性及抗菌性能较差,需进行表面改性以弥补其不足之处。壳聚糖具有良好的生物相容性及成膜性,且可作为载体将目标药物引入钛合金表面,可有效改善钛合金材料的生物学性能,增加其使用范围。本文对近几年壳聚糖表面改性钛合金材料的相关研究进行归纳总结,从壳聚糖涂层改性的方式、钛合金材料成骨性及抗菌性的改善3个方面展开论述,以期为钛合金材料涂层改性在临床中的应用提供指导依据。

Titanium alloy has good biological properties and is commonly used in orthopedics,but its bone integrity and antibacterial properties are poor,so surface modification is needed to make up for its shortcomings.Chitosan has good biocompatibility and film-forming ability,and can be used as a carrier to introduce the target drug to the surface of titanium alloy,which can effectively improve the biological properties of titanium alloy materials and increase its application range.In this paper,the related research of chitosan surface modified titanium alloy materials in recent years is summarized.The modification methods of chitosan coating,the improvement of osteogenesis and antibacterial properties of titanium alloy materials are discussed in order to provide guidance for the clinical application of coating modification of titanium alloy materials.