血小板活化因子在变应性鼻炎中的作用及其研究进展

Role of platelet activating factor and its research progress in allergic rhinitis

血小板活化因子(PAF)是一种强活性的内源性磷脂介质,主要由中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞、肥大细胞、内皮细胞和巨噬细胞等多种免疫细胞受到炎症刺激后释放,在多种炎症性疾病中起着至关重要的作用。近些年在变应性鼻炎(AR)的发病机制研究中发现,PAF作为潜在的相关炎症介质,可以通过影响炎性细胞的趋化作用,改变鼻腔黏膜血管通透性及气道反应性并影响腺体的分泌,从而对AR一些症状的产生起着较关键的作用。目前国际上已有多项临床研究证明,使用PAF抑制剂是干预AR症状的一个有效方法,但是国内关于PAF抑制剂在AR中的应用研究相对甚少。本文就近年来血PAF在AR发病机制中的作用及相关研究进行综述。

Platelet-activating factor(PAF) is a highly active endogenous phospholipid mediator, which is mainly released by a variety of immune cells including neutrophils, eosinophils, basophils, mast cells, endothelial cells and macrophages after being stimulated by inflammation. They play a vital role in many inflammatory diseases. In recent years, studies on the pathogenesis of allergic rhinitis have found that PAF, as a potential related inflammatory mediator, can affect the chemotaxis of inflammatory cells, change the vascular permeability of the nasal mucosa, airway reactivity, and affect the secretion of glands. Therefore, it plays a key role in the appearance of some symptoms of AR. At present, many international clinical studies have proved that the use of PAF inhibitors is a good solution to the symptoms of allergic rhinitis. However, there are relatively few domestic studies on the application of PAF inhibitors in allergic rhinitis. This article reviews the role of platelet activating factor in the pathogenesis of allergic rhinitis and related research in recent years.