缺陷型精神分裂症患者生活质量研究

Quality of life in defective schizophrenia

目的:探讨缺陷型精神分裂症(DS)患者生活质量及其与精神分裂症症状之间的关联。方法:99例诊断明确的精神分裂症患者,将其分为DS组(n=41)和NDS组(n=58),同时纳入57名健康人作为对照组。采用世界卫生组织生存质量测定量表简表(WHOQOL-BREF)和阳性与阴性症状量表(PANSS)对患者进行评估。比较各组间的评分差异,分析DS患者生活质量与临床量表评分之间的关系。结果:DS组和NDS组生活质量总分均低于对照组(P<0.05),两病例组之间生活质量比较,差异无统计学意义(P>0.05),两病例组生活质量总分与PANSS总分、PANSS阳性症状评分、PANSS一般病理评分之间均存在负相关。结论:精神分裂症患者的生活质量显著下降,DS患者精神症状的严重程度,尤其是阳性症状的严重程度与其生活质量更相关。

Objective:To investigate the relationship between quality of life(QOL)and symptoms of schizophrenia in patients with defective schizophrenia(DS).Methods:99 schizophrenic patients were divided into DS group(n=41)and non DS group(n=58),and 57 healthy people were included as control group.The patients were assessed by WHOQOL-BREF and PANSS.The differences of the scores among the groups were compared,and the relationship between the quality of life and the clinical scale score of DS patients were analyzed.Results:The total scores of quality of life in DS group and non DS group were significantly lower than those in control group(P<0.05).There was no significant difference in the total scores of quality of life between the two patients group(P>0.05).There was negative correlation between the total scores of quality of life and the total score of PANSS and the score of PANSS positive symptoms and PANSS general pathology score in the two patients group.Conclusion:The quality of life of schizophrenic patients decreased significantly.The severity of mental symptoms,especially the severity of positive symptoms,is more related to the quality of life environment in schizophrenic patients with defective symptoms.