达原饮在新冠肺炎中的应用及其治疗发热临床效果的系统分析

The Application of Dayuanyin in the Treatment of New Coronary Pneumonia and the Systematic Analysis of its Clinical Effect on Fever

目的总结达原饮在新冠肺炎中的应用,并系统评价达原饮治疗发热的有效性。方法检索PubMed、The Cochrane Library、EMbase、CNKI、WANFANG、VIP,筛选达原饮治疗发热的随机临床对照试验文献,时间为自建库起至2020年4月4日。由2名评价者进行数据提取,使用Review Manager 5.3对文献进行敏感性评价。同时梳理新型冠状病毒感染的肺炎诊疗方案第三至八版,分析推荐处方中达原饮的加减方案并进行归纳总结。结果共纳入RCT文献12篇,总计病例2398个。系统分析结果显示治疗组有效率明显高于对照组([RR=1.11,95%CI(1.06,1.16),P=0.00])。治疗组在体温恢复时间、症状积分方面优于对照组,分析结果均具有统计学意义。连续变量数据临床异质性过大仅作描述性分析。结论达原饮联合疗法治疗发热的疗效确切且治疗效果优于常规疗法。

Objective To summarize the application of Dayuanyin in the treatment of new coronary pneumonia,and to systematically evaluate the effectiveness of Dayuanyin in treating fever.Methods The PubMed,The Cochrane Library,EMbase,CNKI,WANFANG,VIP were searched up from the establishment of the library to April 4,2020 and screened the randomized clinical controlled trial literature of Dayuanyin for the treatment of fever.Data extraction was performed by two reviewers and used Review Manager 5.3 to evaluate the sensitivity of the literature.At the same time,the third to eighth editions of the pneumonia diagnosis and treatment plan for the new coronavirus infection are sorted out,and the addition and subtraction plans for the recommended prescription Dayuanyin are analyzed and summarized.Results A total of 12 RCT documents were included,with a total of 2,398 cases.The results of systematic analysis show that the effective rate of the treatment group is significantly higher than that of the control group(RR=1.11,95%CI[1.06,1.16],P=0.00).The treatment group was superior to the control group in terms of time to recovery of temperature and score of symptoms,the analysis results are statistically significant.The clinical heterogeneity of continuous variable data is too large for descriptive analysis only.Conclusion The effect of Dayuanyin combination therapy on fever is definite and the therapeutic effect is better than conventional therapy.