咪达唑仑联合喹硫平对阿尔兹海默症伴睡眠障碍患者睡眠质量及认知功能的影响

Effects of midazolam combined with quintiapine on sleep quality and cognitive function in patients with Alzheimer’s disease with sleep disorder

目的探讨咪达唑仑联合喹硫平对阿尔兹海默症伴睡眠障碍患者睡眠质量及认知功能的影响。方法选取2016年5月至2017年5月于本院接受治疗的100例阿尔兹海默症伴睡眠障碍患者,按照随机数表法分为对照组和观察组,每组50例。对照组患者采用单一的喹硫平进行治疗,观察组患者在喹硫平治疗的基础上,加用咪达唑仑进行治疗。比较两组患者治疗后的PSQI评分及治疗前后的MMSE评分情况。结果治疗后,观察组睡眠障碍、入睡时间、睡眠质量、睡眠时间、睡眠效率、睡眠药物及日间功能评分均低于对照组,差异有统计学意义(P<0.05)。与治疗前比较,两组患者治疗后MMSE评分均升高,差异具有统计学意义(P<0.05);观察组MMSE评分高于对照组,差异具有统计学意义(P<0.05)。结论咪达唑仑联合喹硫平治疗阿尔兹海默症伴睡眠障碍患者,可有效改善患者睡眠质量,提高患者认知功能。

Objective To investigate the effect of midazolam combined with quintiapine on sleep quality and cognitive function in patients with Alzheimer’s disease(AD)with sleep disorder.Methods According to the random table method,100 patients with Alzheimer’s disease with sleep disorder treated in our hospital from May 2016 to May 2017 were divided into control group and observation group,with 50 cases in each group.The control group was treated with single quintiapine,the observation group were treated with midazolam on the basis of quintiapine treatment.The PSQI score and MMSE score before and after treatment were compared between the two groups.Results After treatment,the sleep disorder,time to fall asleep,sleep quality,sleep time,sleep efficiency,sleep medication and daytime function scores of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).Compared with before treatment,the MMSE scores of the two groups increased after treatment,and the difference was statistically significant(P<0.05).The MMSE score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Midazolam combined with quintiapine can effectively improve the sleep quality and cognitive function of patients with Alzheimer’s disease with sleep disorder.